Psoriasis vulgaris and human leukocyte antigens.
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Researchers: Cassia FF, Carneiro SC, Marques MT, Pontes LF, Filgueira AL, Porto LC.
J Eur Acad Dermatol Venereol. 2007 Mar;21(3):303-10.
School of Medicine, Clementino Fraga Filho University Hospital, Post Graduation Course of Dermatology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Abstract
BACKGROUND:
Psoriasis vulgaris is a skin disease with a complex immunological and genetic background, triggered by environmental factors. The association of human leukocyte antigens (HLA) and psoriasis has long been reported on population and familial studies.
OBJECTIVES:
To review and discuss studies on psoriasis vulgaris and HLA, in Caucasian and non-Caucasian populations.
METHODS:
The major population studies on psoriasis vulgaris and the associated HLA antigens and alleles are described and discussed based on a review of the current literature.
RESULTS:
Population studies demonstrate the presence of different HLA specificities as well as extended haplotypes in patients with psoriasis, when compared to controls. Some alleles occur in a lower frequency in patients with psoriasis, indicating they could be protection alleles. In all studies which HLA class I was typed, Cw6 or Cw*0602 was present in a significant frequency in patients with psoriasis, mainly when early onset and positive family history were considered. HLA-DRB1*0701 was also present in a higher frequency in patients in different populations.
CONCLUSIONS:
Different antigens and alleles from both HLA classes I and II were seen in a significantly higher frequency in patients with psoriasis vulgaris. HLA Cw*0602 and DRB1*0701 were represented in different reports, and the former was related mainly to psoriasis type I.
PMID: 17309450 [PubMed - indexed for MEDLINE
